144 An innovative moisturizer to break inflamm’dryness vicious circle

Dry skin is a common disorder among the general population. It characterized clinically by rough, scaly, and often itchy that has lost its normal mechanical properties (especially loss in elasticity). sign of dysfunction epidermis, especially stratum corneum. This defective barrier function stimulates production secretion cytokines, which turn may cause cutaneous inflammation weaken barrier. Indeed, disruption stimulate signaling cytokine cascades engage not only desired epidermal homeostatic response, but also inflammatory events involving deeper layers endothelium. The elicitation as result can maintain dryness creating vicious circle we called Inflamm’dryness. A botanical extract obtained from Helichrysum stoechas dedifferentiated cells was able to break this circle. First all, induced decrease pro-inflammatory mediators such PGE2 promoted synthesis beneficial molecules resolution regulate homeostasis (e.g. 15-HETE). Moreover, histological TEM analysis clearly showed active ingredient boosted formation corneum: thickness increased 77%. number keratohyalin granules 49% NMF content 29%. demonstrated reduced intercellular spaces between basal keratinocytes (-61%). Finally, helped restore limit dehydration reducing tape-stripping-induced TEWL 78%. In human volunteers with dry skin, moisturization (corneometer) +32% vs. placebo. explants, effect been associated an increase 150% lacunae confirming hydration efficacy. To sum up, leading restoration fine, moisturization.